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Rev. Soc. Bras. Med. Trop ; 40(6): 678-680, nov.-dez. 2007. tab
Article in English | LILACS | ID: lil-471351

ABSTRACT

Two cases of autoimmune hemolytic anemia that occurred during the treatment of chronic hepatitis C with pegylated alpha-2a interferon and ribavirin, in HIV coinfected patients, are presented and described. The late occurrence (after six months of therapy) of this severe hemolytic anemia leads to the recommendation that hemoglobin levels should be monitored throughout the treatment period, even among patients who presented stable hemoglobin levels in the preceding months.


São apresentados e discutidos dois casos de anemia hemolítica auto-imune que ocorreram durante o tratamento da hepatite crônica pelo vírus C, com interferon peguilado alfa 2a e ribavirina, em pacientes co-infectados pelo HIV. A ocorrência de anemia hemolítica grave em etapa tardia, após o sexto mês da terapêutica, recomenda que o controle dos níveis de hemoglobina deva ser feito durante todo o período do tratamento , mesmo nos pacientes que apresentam níveis estáveis de hemoglobina nos meses precedentes.


Subject(s)
Humans , Male , Middle Aged , Anemia, Hemolytic, Autoimmune/chemically induced , Antiviral Agents/adverse effects , HIV Infections/drug therapy , Hepatitis C, Chronic/drug therapy , Interferon-alpha/adverse effects , Ribavirin/adverse effects , Anemia, Hemolytic, Autoimmune/diagnosis , Antiviral Agents/therapeutic use , Drug Therapy, Combination , HIV Infections/complications , Hepatitis C, Chronic/complications , Interferon-alpha/therapeutic use , Ribavirin/therapeutic use
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